abstract：:Colon carcinoma is one of the most common cancers worldwide. Epidemiological studies have revealed that colon cancer is the third leading cause of cancer‑related deaths, which is due to the increased incidence and mortality rates. However, the treatment strategies for colon cancer remain unsatisfactory for patients, e...

authors： Li Z,Zhu Z,Wang Y,Wang Y,Li W,Wang Z,Zhou X,Bao Y

更新日期：2021-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is recognized as a common type of human cancer, and KRAS mutations are correlated with poor CRC survival outcomes. The evaluation and prediction of CRC results remain challenging. In the present study, RNA sequencing and clinical data from The Cancer Genome Atlas were used to identify KRAS muta...

authors： Xu J,Huang QY,Ge CJ

更新日期：2021-10-01 00:00:00

abstract：:Limited access to mental health and behavioral interventions is a public health issue that predated and is further worsened by coronavirus disease 2019 (COVID-19) social distancing restrictions. The Healthy Action to Benefit Independence and Thinking (HABIT) program is a cognitive rehabilitation and wellness program f...

authors： Locke DEC,Khayoun R,Shandera-Ochsner AL,Cuc A,Eilertsen J,Caselli M,Abrew K,Chandler MJ

更新日期：2021-10-01 00:00:00

abstract：:The presence of cancer stem cells (CSCs) is a major cause of therapeutic failure in a variety of cancer types, including colorectal cancer (CRC). However, the underlying mechanisms that regulate the self‑renewal of colorectal cancer stem cells (CRCSCs) remain unclear. Our previous study utilized CRCSCs and their paren...

authors： Chen ZQ,Yuan T,Jiang H,Yang YY,Wang L,Fu RM,Luo SQ,Zhang T,Wu ZY,Wen KM

更新日期：2021-10-01 00:00:00

abstract：...

authors： Yang L,Zheng S,Liu Q,Liu T,Zhang Q,Han X,Tuerxun A,Lu X

更新日期：2021-10-01 00:00:00

abstract：:In a previous study, we suggested that the Hsp90 inhibitor 17-AAG prevents cardiac dysfunction in the failing heart following myocardial infarction in rats. Although it is assumed that the RIP1/RIP3/MLKL necroptotic pathway, which comprises client proteins for Hsp90, is involved; however, the relationship between the ...

authors： Marunouchi T,Ito T,Onda S,Kyo L,Takahashi K,Uchida M,Yano E,Tanonaka K

更新日期：2021-10-01 00:00:00

abstract：:Atherosclerosis (AS) is a chronic inflammatory process initiated when lipoprotein is retained in the arterial wall. Leukocyte recruitment accelerates this process. CXC chemokine ligand 16 (CXCL16) acts as a chemokine to attract immune cells and also facilitates the phagocytosis process of modified low‑density lipoprot...

authors： Zhao J,Yang M,Wu J

更新日期：2021-10-01 00:00:00

abstract：:To investigate the changes of circular (circ)RNA circCD151 expression in lung cancer tissues and cells and its effects on proliferation, migration and invasion of lung cancer cells. The relative expression levels of circCD151 in lung cancer tissues and lung cancer cells (A549 and NCI‑H292) were determined by reverse t...

authors： Zhao L,Zheng H,Jiang P

更新日期：2021-10-01 00:00:00

abstract：:Schnyder's crystalline corneal dystrophy (SCCD) is a rare autosomal dominant genetic disorder that is characterized by progressive corneal opacity, owing to aberrant accumulation of cholesterol and phospholipids in the cornea. A number of SCCD affected families have been reported in the world since 1924, when it was f...

authors： Xie J,Li L

更新日期：2021-10-01 00:00:00

abstract：:Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the flow cytometric data shown in Fig. 3, and western blotting assay data shown in Fig. 6F, were strikingly similar to data appearing in different form in other articles by different authors. Owing to ...

authors： Chen Y,Zhang Z,Luo C,Chen Z,Zhou J

更新日期：2021-10-01 00:00:00

abstract：:Bacillus licheniformis α-amylase is a thermostable enzyme used in industrial starch hydrolysis. However, difficulties in the genetic manipulation of B. licheniformis hamper further enhancement of α-amylase production. In this regard, adaptive evolution is a useful strategy for promoting the productivity of microbial h...

authors： Zhang G,Chen Y,Li Q,Zhou J,Li J,Du G

更新日期：2021-10-01 00:00:00

abstract：:This study explored the quantitative mechanisms of heterotrophic nitrification-aerobic denitrification (HN-AD) in a pilot-scale two-stage tidal flow constructed wetland (TFCW). The TFCW packed shale ceramsite (SC) and activated alumina (AA) at each stage, respectively, and aimed to improve decentralized wastewater tre...

authors： Tan X,Yang YL,Liu YW,Li X,Zhu WB

更新日期：2021-10-01 00:00:00

abstract：:Producing bio-based chemicals is imperative to establish an eco-friendly circular bioeconomy. However, the compromised titer of these biochemicals hampers their commercial implementation. Advances in genetic engineering tools have enabled researchers to develop robust strains producing desired titers of the next-gener...

authors： Aamer Mehmood M,Shahid A,Malik S,Wang N,Rizwan Javed M,Nabeel Haider M,Verma P,Umer Farooq Ashraf M,Habib N,Syafiuddin A,Boopathy R

更新日期：2021-10-01 00:00:00

abstract：:The feasibility of producing polyhydroxyalkanoate (PHA) from pretreated waste wood hydrolysate and volatile fatty acids (VFAs) from sewage fermented products as co-substrate feedstock through mixed microbial cultures (MMCs) process was explored. The results showed that the addition of co-substrate shortened the cycle ...

authors： Li D,Ma X,Li J,Sun B

更新日期：2021-10-01 00:00:00

abstract：:Non-sterile heterotrophic cultivation of Galdieria sulphuraria in presence of digestate as well as straw after hydrolysis was investigated. G. sulphuraria can be grown in pure digestate at rates of 0.9 day-1 with glucose. However, a proteolytic treatment of digestate resulted in increased growth rates (1.2 day-1) and ...

authors： Pleissner D,Lindner AV,Händel N

更新日期：2021-10-01 00:00:00

abstract：Background:Nordic walking (NW) has been reported as a safe and effective exercise mode. However, the effects of NW on cognitive function are unknown. This study examined the effects of an unsupervised NW intervention on cognitive and physical function among older women engaging in volunteering. Methods:Forty-seven wom...

authors： Nemoto Y,Sakurai R,Ogawa S,Maruo K,Fujiwara Y

更新日期：2021-10-01 00:00:00

abstract：:Under the current pandemic situation caused by the novel coronavirus SARS-CoV-2, wastewater monitoring has been increasingly investigated as a surveillance tool for community-wide disease prevalence. After a year into the pandemic, this review critically discusses the real progress made in the detection of SARS-CoV-2 ...

authors： Pulicharla R,Kaur G,Brar SK

更新日期：2021-10-01 00:00:00

abstract：Introduction:The first COVID-19 cases occurred in the US in January of 2020, leading to the implementation of shelter in place. This study seeks to define the impact of shelter in place on the epidemiology of pediatric trauma. Methods:We examined pediatric trauma admissions at 5 Level 1 and 1 Level 2 US pediatric trau...

authors： Bessoff KE,Han RW,Cho M,Stroud M,Urrechaga EM,Thorson CM,Russell KW,Rohan A,Acker SN,Swain S,Malvezzi L,Fuchs JR,Chao SD

更新日期：2021-10-01 00:00:00

abstract：:A cellulose-based microgel is firstly synthesized via chemically coupling gelatin and cellulose, and then amphiphilic cellulose copolymers (HMGC) are prepared by alkylated cellulose-based microgel from different long-chain alkyl groups. The long-chain alkyl group is mainly bonded onto the residual hydroxyl group at C6...

authors： Yao Y,Zhou D,Shen Y,Wu H,Wang H

更新日期：2021-10-01 00:00:00

abstract：:A series of cationic starches with different degrees of substitution were synthesized by etherification of potato starch with 3-chloro-2-hydroxypropyl trimethylammonium chloride (CTA). Cationic starch nanoparticles (CTA-StNPs) with different sizes were prepared by precipitation. Flocculation behaviors of the CTA-StNPs...

authors： Chang Y,Hu Z,Wang P,Zhou J

更新日期：2021-10-01 00:00:00

abstract：:This study is focused on enhancing the stability of mechanical and chemical properties of thermoplastic starch (TPS) by dual crosslinking strategy through melt processing conditions. The dually crosslinked TPS was prepared by in situ reaction of starch, glycerol, and epichlorohydrin (ECH), resulting in both noncovalen...

authors： Peidayesh H,Heydari A,Mosnáčková K,Chodák I

更新日期：2021-10-01 00:00:00

abstract：:To improve the efficacy of chemotherapy and relieve the pain associated with colorectal cancer, a dual-drug delivery system (DDDS) is proposed. In this system, methotrexate (MTX) loaded CaCO3 (CaCO3/MTX) and aspirin (Asp) are co-entrapped in the hydrogels of alginate (Alg) and sodium carboxymethyl cellulose (CMC) cros...

authors： Sheng Y,Gao J,Yin ZZ,Kang J,Kong Y

更新日期：2021-10-01 00:00:00

abstract：:Hyaluronan (HA) has been widely used as a dietary supplement which can be degraded by gut microbiota. However, the interactions between HA and gut microbiota have not been fully characterized. Here, using an in vitro system, we found that HA is readily fermented by human gut microbiota but with differing fermentative ...

authors： Pan L,Ai X,Fu T,Ren L,Shang Q,Li G,Yu G

更新日期：2021-10-01 00:00:00

abstract：:Bio-based aerogel (polysaccharide cryogel) have led to a growing interest because of eco-friendliness, sustainability and excellent thermal insulation properties. Herein, we report an eco-friendly strategy to construct lightweight and porous sodium alginate/carboxymethyl cellulose/chitosan polysaccharide-based composi...

authors： He H,Wang Y,Yu Z,Liu J,Zhao Y,Ke Y

更新日期：2021-10-01 00:00:00

abstract：:In this paper, N-methylene phosphonic acid chitosan (NPCS-PEI) was synthesized from chitosan, phosphorous acid, formaldehyde and hyperbranched polyethyleneimine (PEI), and Cu2+ and Pb2+ removal performance was examined in aqueous solution. NPCS-PEI exhibited three-dimensional porous architectures, with a specific surf...

authors： Liu T,Gou S,He Y,Fang S,Zhou L,Gou G,Liu L

更新日期：2021-10-01 00:00:00

abstract：:Endogenous and exogenous sulfated polysaccharides exhibit potent biological activities, including inhibiting blood coagulation and protein interactions. Controlled chemical sulfation of alternative polysaccharides holds promise to overcome limited availability and heterogeneity of naturally sulfated polysaccharides. H...

authors： Solhi L,Sun HS,Daswani SH,Shojania S,Springate CMK,Brumer H

更新日期：2021-10-01 00:00:00

abstract：:The understanding of the photochemistry of antibiotic compounds is important because it gives the direct information on the possible environmental pollution caused by them. Due to their large size, the theoretical studies of their excited-state reactions are rather challenging. In current work, we combined the on-the-...

authors： Lin K,Hu D,Peng J,Xu C,Gu FL,Lan Z

更新日期：2021-10-01 00:00:00

abstract：Background:The coronavirus disease 2019 (COVID-19) pandemic is a worldwide epidemiological emergency, and the risk factors for the multiple waves with new COVID-19 strains are concerning. This study aims to identify the most significant risk factors for spreading COVID-19 to help policymakers take early measures for th...

authors： Mashrur FR,Roy AD,Chhoan AP,Sarker S,Saha A,Hasan SMN,Saha S

更新日期：2021-10-01 00:00:00

abstract：:The COVID-19 pandemic forced the Dutch national breast screening program to a halt in week 12, 2020. In week 26, the breast program was resumed at 40% capacity, which increased to 60% in week 34. We examined the impact of the suspension and restart of the screening program on the incidence of screen-detected and non-s...

authors： Eijkelboom AH,de Munck L,Lobbes MBI,van Gils CH,Wesseling J,Westenend PJ,Guerrero Paez C,Pijnappel RM,Verkooijen HM,Broeders MJM,Siesling S,NABON COVID-19 Consortium and the COVID and Cancer-NL Consortium.

更新日期：2021-10-01 00:00:00

abstract：:Aldehydes are toxic carbonyl compounds that are identified in various matrices surrounding us. For instance, aldehydes could be formed during the cooking and frying of foods which affects the food quality and safety. Derivatization is a must for the determination of aldehydes as they lack intrinsic chromophoric groups...

authors： El-Maghrabey M,Suzuki H,Kishikawa N,Kuroda N

更新日期：2021-10-01 00:00:00

abstract：:A wide range of strategies for efficient chromatography and high MS sensitivity in reversed-phase LC-MS analysis of antibody biopharmaceuticals and their large derivates has been evaluated. They included replacing trifluoroacetic acid with alternative acidifiers, relevancy of elevated column temperature, use of dedica...

authors： Khalikova MA,Skarbalius L,Naplekov DK,Jadeja S,Švec F,Lenčo J

更新日期：2021-10-01 00:00:00

abstract：:As a biomarker of several diseases, the activity of acid phosphatase (ACP) is generally used to assistantly diagnose these diseases. Thus, developing reliable ACP activity analytical methods becomes quite significant. Herein, we recommend a one-step sampling filtration-free electrochemical method for ACP activity dete...

authors： Ye K,Zhang M,Liu P,Liu B,Xu X,Li X,Zhu H,Wang L,Wang M,Niu X

更新日期：2021-10-01 00:00:00

abstract：:Flow analysis is usually associated with repetitive assays, as all samples of a batch are generally handled in the same way. By exploiting computer-controlled devices (e.g. pumps, valves, injectors, commuters, and samplers), this scenario has been expanded, as a proper manifold dimensioning can be set for each sample....

authors： Zagatto EAG,Rocha FRP

更新日期：2021-10-01 00:00:00

abstract：:Recent virus outbreaks have revealed a critical need for large scale serological assays. However, many available tests either require a cumbersome, costly apparatus or lack the availability of full automation. In order to address these limitations, we describe a homogeneous assay for antibody detection via measurement...

authors： Temurok N,Leon F,Pinchon E,Clot M,Foulongne V,Cantaloube JF,Vande Perre P,Fournier-Wirth C,Molès JP,Daynès A

更新日期：2021-10-01 00:00:00

abstract：:A method using a gas-phase microdialysis probe interfaced with a modified commercially available nitric oxide (NO) detector is shown to selectively measure aqueous NO at low μM levels with high selectivity. The detector measures chemiluminescence resulting from the gas-phase reaction of NO with ozone. The microdialysi...

authors： Humbert M,Lewis S,Borgerding A

更新日期：2021-10-01 00:00:00

abstract：:Phosphopeptides were of great significance in disease diagnosis and monitoring its dynamic changes. In this article, we proposed a more efficient method to synthesize a kind of bimetallic mesoporous silica nanomaterials (Fe3O4@mSiO2-PO3-Ti4+/Zr4+) and applied it to the analysis of phosphopeptides in human saliva sampl...

authors： Fang X,Liu X,Sun N,Deng C

更新日期：2021-10-01 00:00:00

abstract：:Single-cell analysis has gained considerable attention for disease diagnosis, drug screening, and differentiation monitoring. Compared to the well-established flow cytometry, which uses fluorescent-labeled antibodies, microfluidic impedance cytometry (MIC) offers a simple, label-free, and noninvasive method for counti...

authors： Zhu S,Zhang X,Zhou Z,Han Y,Xiang N,Ni Z

更新日期：2021-10-01 00:00:00

abstract：:Accurate and effective detection of single-stranded nucleic acids is vital in both disease diagnosis and pathological studies. Hence, we develop a PAMmer-assisted CRISPR/Cas9 system mediated G4-EXPAR (Cas-G4EX) strategy for site-specific detection of ssRNA and ssDNA. PAMmer-assisted CRISPR/Cas9 executes the site-speci...

authors： Wang X,Chen X,Chu C,Deng Y,Yang M,Huo D,Xu F,Hou C,Lv J

更新日期：2021-10-01 00:00:00

abstract：:Direct molecular analysis of tissue samples is a promising approach to increase the accuracy, speed and molecular specificity of cancer diagnosis. Herein, alterations of amino acids between human lung cancer tissues and matched adjacent normal tissues were profiled by internal extraction electrospray ionization mass s...

authors： Lu H,Li Y,Zhang H,Chingin K,Wei Y,Huang K,Feng S

更新日期：2021-10-01 00:00:00

abstract：:The behaviors of internal standards, according to different flow rates of the cell collision gas (He), were studied for the determination of Cd, Pb, Pd, Pt, Rh, and Sn in samples of fish and mollusks by inductively coupled plasma mass spectrometry (ICP-MS). The elements Bi, Ge, In, Sc, and Y were selected as internal ...

authors： Moreira LS,Costa FS,Machado RC,Nogueira ARA,Gonzalez MH,da Silva EGP,Amaral CDB

更新日期：2021-10-01 00:00:00